![]() ![]() Identification and susceptibility testing may therefore lead to more effective treatment and may prevent the development of resistance among patients with advanced cancer. Different Candida species occur in both mono and mixed infections. albicans was the predominant species, with a high susceptibility to antifungal agents. albicans species were resistant to fluconazole, one to amphotericin B and three to anidulafungin. albicans strains, 39 out of 40 were susceptible to fluconazole. Thirty-six patients had mono infection, and nine out of 45 patients had 2–3 different species detected. The results of biochemical identification were confirmed with sequencing analysis. Seven different Candida species and one Saccharomyces species were detected. Resultsįifty-six isolates from 45 patients were identified. Etest was performed on RPMI agar, and the antifungals fluconazole, amphotericin B, anidulafungin and nystatin were applied. Single colony of each species was re-cultivated and prepared for biochemical identification with a VITEK2® system and verified by gene sequencing. Isolates were re-grown on chromID® Candida plates in 2020. Clinical fungal isolates were collected from patients in a hospice unit in 2014–2016. MethodsĪn observational study with microbiological analysis was conducted. This study aimed to assess the diversity and antifungal susceptibility of Candida species detected in the oral cavity. albicans are associated with varying degrees of resistance to azoles, which may have implications for treatment. Studies of oral fungal samples show an increased prevalence of non- Candida albicans species in mixed oral infections with Candida albicans. Patients with advanced cancer are prone to develop different opportunistic oral infection due to anti-cancer treatment or the malignancies themselves.
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